{"schema":"sb.node.v1","id":"sb:e/187b6464786cdfff0173aea7","kind":"entity","label":{"text":"mapk","locale":"en"},"identity":{"anchor":"label:en:mapk","strength":"label"},"asOf":{"knowledgeCutoff":"2026-10-10T23:27:45.667496+00:00","snapshot":"deploy 43355a5524557b01da9d6baf1a1f21db49beadc9"},"lens":{"kind":"public"},"build":{"plane":"projected","builtFrom":["entity_graph.slim.json","entity_receipts (deploy asset)","event_graph.json","truth_records (deploy asset)","corroborated_record.json"],"rule":"node-projection.entity@v1"},"standing":{"evidence":{"supporting":31,"separatePublishers":12,"basis":"documents that mention the subject and the outlets that carried them; a mention is evidence the referent is in use, not evidence about any claim","receiptsOnTopic":{"state":"partial","share":0.387,"named":12,"of":31,"basis":"documents whose own title or summary lead names the subject, over every counted document that mentions it anywhere (the entity graph's measurement); receipts are drawn from the former only","blind":["only 39% of the 31 documents measured name the subject in their own text; the rest mention it in passing, so standing.evidence.supporting overstates coverage about it"]}},"admission":{"state":"canonical","reason":"entity graph provenance 'curated'; the node carries no promotion receipt in v1","policy":"EQ-PROMOTION (receipt not carried)"},"disposition":{"state":"served","reason":"public record"},"validity":{"from":"2026-03-15","to":"2026-10-08","basis":"first and last day we saw it mentioned; not the subject's own lifetime"},"measurement":{"state":"partial","blind":["assertion coverage 0.032: about 97% of mentions carry no typed assertion"]}},"dimensions":{"domains":["oncology","preprint"],"activeDays":25,"assertions":{}},"up":[],"upNote":"An entity is a root: it is contained by nothing. Pan out by following R.","children":{"count":6,"byKind":{"observation":6},"items":[{"id":"sb:o/ef1e0c45681812781f0dce8d","kind":"observation","label":"bioRxiv Cancer Biology · 2026-10-06 · p38α MAPK integrates opposing oncogenic APC/β-catenin/TCF and GUCY2C tumor-suppressor axes in colorectal cancer","url":"https://www.biorxiv.org/content/10.64898/2026.10.05.756833v1?rss=1"},{"id":"sb:o/9ebf8cc3c2e7f4572595d66f","kind":"observation","label":"bioRxiv Cancer Biology · 2026-10-06 · Binding kinetics enable tumor-selective MAPK and growth suppression by a Type 1 RAF Inhibitor","url":"https://www.biorxiv.org/content/10.64898/2026.10.05.756774v1?rss=1"},{"id":"sb:o/b861342372c324d402c3eaa8","kind":"observation","label":"bioRxiv Cancer Biology · 2026-09-28 · Pathway-wide base editing charts chemical-genetic interactions in MAPK signaling","url":"https://www.biorxiv.org/content/10.64898/2026.09.25.753639v1?rss=1"},{"id":"sb:o/e1facf739ad419b69f84ccf2","kind":"observation","label":"bioRxiv Cancer Biology · 2026-09-15 · HrasG12V induces follicular thyroid cancer with attenuated MAPK activation and increased latency compared to KrasG12D","url":"https://www.biorxiv.org/content/10.64898/2026.09.09.750413v1?rss=1"},{"id":"sb:o/41df8d3833505d4562f793a0","kind":"observation","label":"bioRxiv · 2026-09-15 · Hras G12V induces follicular thyroid cancer with attenuated MAPK activation and increased latency compared to Kras G12D.","url":"https://doi.org/10.64898/2026.09.09.750413"},{"id":"sb:o/2f3e3f5c2b8d845552e8d55d","kind":"observation","label":"GEN · 2026-09-18 · Kidney Organoids Reveal Inflammatory Drivers of Diabetic Kidney Disease","url":"https://www.genengnews.com/topics/translational-medicine/kidney-organoids-reveal-inflammatory-drivers-of-diabetic-kidney-disease/"}],"cursor":null,"order":"newest first; we keep the 6 newest receipts for this entity whose own title or summary lead (the entity graph's test) names it. Its other observations are counted in standing.evidence.supporting but are not addressable in v1"},"relations":{"count":{"state":"cannot-measure","reason":"claims: this subject's maintained record could not be read (the maintained record \"mapk\" could not measure its claims: this subject was retired from the publication registry on 2026-10-04 (no longer clears the admission conditions — re-checked 2026-10-04 (no receipt in the corpus-evidence shard for this label)); the record is kept as a dated tombstone and is no longer maintained). The items listed come from the passes that could be read"},"byKind":{"co-mentioned":4},"items":[{"kind":"relation","label":"co-mentioned with kras (14 documents)","role":"co-mentioned","relationKind":"co-mentioned","members":2,"id":"sb:r/3cd1c5ac09a95329baa552f8"},{"kind":"relation","label":"co-mentioned with pi3k (14 documents)","role":"co-mentioned","relationKind":"co-mentioned","members":2,"id":"sb:r/314a7341e2c152be62731c6b"},{"kind":"relation","label":"co-mentioned with colorectal cancer (12 documents)","role":"co-mentioned","relationKind":"co-mentioned","members":2,"id":"sb:r/232fc1541a93043323aadf5c"},{"kind":"relation","label":"co-mentioned with nuclear (9 documents)","role":"co-mentioned","relationKind":"co-mentioned","members":2,"id":"sb:r/021eab61c4a9fb47cba15a64"}],"cursor":null,"order":"situations first, then claims (the subject's own maintained record, then site-wide corroborated clusters; each label ends with its standing), then co-mentions by shared documents, descending. Co-mentions are the ten strongest the entity graph keeps per entity"},"edge":{"state":"continues"},"links":{"rest":"/api/v1/node/e/187b6464786cdfff0173aea7","mcp":"traverse {\"id\":\"sb:e/187b6464786cdfff0173aea7\"}","page":"/entity/mapk/"},"limits":{"levelsPerCall":1,"pageSize":10,"maxPageSize":50,"membersMax":50,"statement":"One level per call: depth is 1 and only 1, and there is no whole-graph dump. pageSize 1-50 (default 10); a page limit is a cursor, never an edge. Members are listed up to 50. At most 60 traverse calls a minute per caller (runaway-loop protection, not a meter). One knowledge cutoff is served: the deploy's."},"actions":[{"verb":"unfold","lit":true,"effect":"read","layer":"cantina","call":"traverse {\"id\":\"sb:e/187b6464786cdfff0173aea7\",\"level\":\"children\"}"},{"verb":"fold","lit":true,"effect":"read","layer":"cantina","call":"traverse {\"id\":\"sb:e/187b6464786cdfff0173aea7\"}"},{"verb":"panOut","lit":false,"effect":"read","layer":"cantina","reason":"An entity is a root: it is contained by nothing. Pan out by following R."},{"verb":"follow","lit":true,"effect":"read","layer":"cantina","call":"traverse {\"id\":\"sb:e/187b6464786cdfff0173aea7\",\"level\":\"relations\"}"},{"verb":"receipts","lit":false,"effect":"read","layer":"cantina","reason":"receipts are the observations below this node; unfold to reach them"},{"verb":"edge","lit":true,"effect":"read","layer":"cantina","call":"traverse {\"id\":\"sb:e/187b6464786cdfff0173aea7\"}"},{"verb":"asOf","lit":false,"effect":"read","layer":"cantina","reason":"v1 serves one knowledge cutoff, this deploy's; walking an earlier cutoff needs retained history (EQ-REPLAY), which v1 does not keep"},{"verb":"switchObserver","lit":false,"effect":"read","layer":"cantina","reason":"the public record is the same for every observer; traversal through a Watch's lens is not served in v1"},{"verb":"readOriginal","lit":false,"effect":"read","layer":"cantina","reason":"no translation is applied on this node; every label is the source's own text"},{"verb":"save","lit":false,"effect":"watch-declaration","layer":"workshop","reason":"saving applies to a configured Watch; configure one around this node first (free), then save it"},{"verb":"deliver","lit":false,"effect":"watch-declaration","layer":"workshop","reason":"delivery applies to a saved Watch"},{"verb":"format","lit":false,"effect":"watch-declaration","layer":"workshop","reason":"output format applies to a saved Watch"},{"verb":"deltaR","lit":false,"effect":"read","layer":"workshop","reason":"Delta R needs a saved Watch with a previous reading"},{"verb":"read","lit":false,"effect":"read","layer":"docking-bay","reason":"one-time Reads are parked until the Commander decides their shape (#938)"}]}