{"schema":"sb.node.v1","id":"sb:e/6ee9dc5d1bc32123455fcb52","kind":"entity","label":{"text":"ctdna","locale":"en"},"identity":{"anchor":"label:en:ctdna","strength":"label"},"asOf":{"knowledgeCutoff":"2026-10-10T17:30:17.444527+00:00","snapshot":"deploy d3689e88c5960e221ab0ad8059cbed523c0447fc"},"lens":{"kind":"public"},"build":{"plane":"projected","builtFrom":["entity_graph.slim.json","entity_receipts (deploy asset)","event_graph.json","truth_records (deploy asset)","corroborated_record.json"],"rule":"node-projection.entity@v1"},"standing":{"evidence":{"supporting":234,"separatePublishers":87,"basis":"documents that mention the subject and the outlets that carried them; a mention is evidence the referent is in use, not evidence about any claim","receiptsOnTopic":{"state":"measured","share":0.718,"named":168,"of":234,"basis":"documents whose own title or summary lead names the subject, over every counted document that mentions it anywhere (the entity graph's measurement); receipts are drawn from the former only"}},"admission":{"state":"canonical","reason":"entity graph provenance 'curated'; the node carries no promotion receipt in v1","policy":"EQ-PROMOTION (receipt not carried)"},"disposition":{"state":"served","reason":"public record"},"validity":{"from":"2026-03-11","to":"2026-10-09","basis":"first and last day we saw it mentioned; not the subject's own lifetime"},"measurement":{"state":"partial","blind":["assertion coverage 0.128: about 87% of mentions carry no typed assertion"]}},"dimensions":{"domains":["oncology","pubmed_targeted"],"activeDays":118,"assertions":{}},"up":[],"upNote":"An entity is a root: it is contained by nothing. Pan out by following R.","children":{"count":9,"byKind":{"observation":9},"withheld":{"state":"withheld","count":3,"reason":"3 receipts withheld: no source link (the same rule the topic record applies)"},"items":[{"id":"sb:o/b1c4160ef34558147cc32f65","kind":"observation","label":"Ann Oncol · 2026-10-07 · Postoperative ctDNA dynamics and eligibility for Treat-on-Molecular Result (TOMR) ALTAIR trial in colorectal cancer: insights from CIRCULATE-Japan.","url":"https://doi.org/10.1016/j.annonc.2026.09.016"},{"id":"sb:o/88319385c560993b04f13543","kind":"observation","label":"bioRxiv Cancer Biology · 2026-09-28 · ctDNA Release Heterogeneity in Luminal Breast Cancer Revealed by Single-Cell Multi-Omics Spatial Analysis","url":"https://www.biorxiv.org/content/10.64898/2026.09.27.754855v1?rss=1"},{"id":"sb:o/eb15040726b5b03c1541f9b9","kind":"observation","label":"bioRxiv Cancer Biology · 2026-09-22 · Explaining and predicting pseudoprogression in immunotherapythrough joint modeling of immune infiltration and ctDNA dynamics","url":"https://www.biorxiv.org/content/10.64898/2026.09.18.752698v1?rss=1"},{"id":"sb:o/adf5c707b24fe17cf10f6237","kind":"observation","label":"medRxiv Oncology · 2026-09-20 · Methylation-Based ctDNA for Post-Treatment Surveillance of Non-Viral Head and Neck Cancer","url":"https://www.medrxiv.org/content/10.64898/2026.09.17.26363361v1?rss=1"},{"id":"sb:o/abe2b903e1e3ee214ab3ff8d","kind":"observation","label":"J Liq Biopsy · 2026-09-19 · A streamlined hybrid-capture and genome-wide multi-omic platform for highly sensitive ctDNA minimal residual disease monitoring.","url":"https://doi.org/10.1016/j.jlb.2026.100496"},{"id":"sb:o/01ce4ceb77087cba24b7bb64","kind":"observation","label":"J Gastrointest Cancer · 2026-09-16 · Postoperative ctDNA-Guided Adjuvant Therapy in Resected Colorectal Cancer: A Systematic Review and Meta-analysis of Prognostic Validity Versus Treatment-Decision …","url":"https://doi.org/10.1007/s12029-026-01578-9"},{"id":"sb:o/8ce79e921bcbd8b9dd9b5468","kind":"observation","label":"Onco Targets Ther · 2026-09-15 · ctDNA in the Management of Resectable & Advanced Colorectal Cancer: Current Status and Future Directions.","url":"https://doi.org/10.2147/OTT.S619488"},{"id":"sb:o/d7f213985efb216d01dc2b17","kind":"observation","label":"JCO Precision Oncology · 2026-09-13 · Relative Mutant Allele Frequency Role in ctDNA-Guided Anti–Epidermal Growth Factor Receptor Rechallenge in Metastatic Colorectal Cancer","url":"https://ascopubs.org/doi/abs/10.1200/PO-26-00199?af=R"},{"id":"sb:o/4c2e2d6a3ab30f5170588326","kind":"observation","label":"European Journal of Cancer · 2026-09-13 · High-dose furmonertinib plus bevacizumab and intrathecal pemetrexed for EGFR-RAD51 fusion-positive lung adenocarcinoma with leptomeningeal metastasis: Insigh…","url":"https://www.sciencedirect.com/science/article/pii/S0959804926007677?dgcid=rss_sd_all"}],"cursor":null,"order":"newest first; we keep the 9 newest receipts for this entity whose own title or summary lead (the entity graph's test) names it. Its other observations are counted in standing.evidence.supporting but are not addressable in v1"},"relations":{"count":10,"byKind":{"co-mentioned":10},"items":[{"kind":"relation","label":"co-mentioned with colorectal cancer (125 documents)","role":"co-mentioned","relationKind":"co-mentioned","members":2,"id":"sb:r/d0b41581dc91b4684c534b23"},{"kind":"relation","label":"co-mentioned with immunotherapy (39 documents)","role":"co-mentioned","relationKind":"co-mentioned","members":2,"id":"sb:r/9930d937dc7331bf0e89c8aa"},{"kind":"relation","label":"co-mentioned with fda (37 documents)","role":"co-mentioned","relationKind":"co-mentioned","members":2,"id":"sb:r/5d3b957e35651e90901223a9"},{"kind":"relation","label":"co-mentioned with breast cancer (34 documents)","role":"co-mentioned","relationKind":"co-mentioned","members":2,"id":"sb:r/66e12c3dea3e478bc5a8c6af"},{"kind":"relation","label":"co-mentioned with ai (30 documents)","role":"co-mentioned","relationKind":"co-mentioned","members":2,"id":"sb:r/8caef956a96cf96a77257635"},{"kind":"relation","label":"co-mentioned with lung cancer (28 documents)","role":"co-mentioned","relationKind":"co-mentioned","members":2,"id":"sb:r/d22522a24b078d75155ef889"},{"kind":"relation","label":"co-mentioned with united states (25 documents)","role":"co-mentioned","relationKind":"co-mentioned","members":2,"id":"sb:r/8a3a9342b21db2490d12d8f3"},{"kind":"relation","label":"co-mentioned with solid tumors (22 documents)","role":"co-mentioned","relationKind":"co-mentioned","members":2,"id":"sb:r/5ebf296a67211d5889cd28f5"},{"kind":"relation","label":"co-mentioned with her2 (22 documents)","role":"co-mentioned","relationKind":"co-mentioned","members":2,"id":"sb:r/d4fb7bfbed0e18709a2cb196"},{"kind":"relation","label":"co-mentioned with t-cell (21 documents)","role":"co-mentioned","relationKind":"co-mentioned","members":2,"id":"sb:r/786b58acdb80910b870d40c0"}],"cursor":null,"order":"situations first, then claims (the subject's own maintained record, then site-wide corroborated clusters; each label ends with its standing), then co-mentions by shared documents, descending. Co-mentions are the ten strongest the entity graph keeps per entity"},"edge":{"state":"continues"},"links":{"rest":"/api/v1/node/e/6ee9dc5d1bc32123455fcb52","mcp":"traverse {\"id\":\"sb:e/6ee9dc5d1bc32123455fcb52\"}","page":"/entity/ctdna/"},"limits":{"levelsPerCall":1,"pageSize":10,"maxPageSize":50,"membersMax":50,"statement":"One level per call: depth is 1 and only 1, and there is no whole-graph dump. pageSize 1-50 (default 10); a page limit is a cursor, never an edge. Members are listed up to 50. At most 60 traverse calls a minute per caller (runaway-loop protection, not a meter). One knowledge cutoff is served: the deploy's."},"actions":[{"verb":"unfold","lit":true,"effect":"read","layer":"cantina","call":"traverse {\"id\":\"sb:e/6ee9dc5d1bc32123455fcb52\",\"level\":\"children\"}"},{"verb":"fold","lit":true,"effect":"read","layer":"cantina","call":"traverse {\"id\":\"sb:e/6ee9dc5d1bc32123455fcb52\"}"},{"verb":"panOut","lit":false,"effect":"read","layer":"cantina","reason":"An entity is a root: it is contained by nothing. Pan out by following R."},{"verb":"follow","lit":true,"effect":"read","layer":"cantina","call":"traverse {\"id\":\"sb:e/6ee9dc5d1bc32123455fcb52\",\"level\":\"relations\"}"},{"verb":"receipts","lit":false,"effect":"read","layer":"cantina","reason":"receipts are the observations below this node; unfold to reach them"},{"verb":"edge","lit":true,"effect":"read","layer":"cantina","call":"traverse {\"id\":\"sb:e/6ee9dc5d1bc32123455fcb52\"}"},{"verb":"asOf","lit":false,"effect":"read","layer":"cantina","reason":"v1 serves one knowledge cutoff, this deploy's; walking an earlier cutoff needs retained history (EQ-REPLAY), which v1 does not keep"},{"verb":"switchObserver","lit":false,"effect":"read","layer":"cantina","reason":"the public record is the same for every observer; traversal through a Watch's lens is not served in v1"},{"verb":"readOriginal","lit":false,"effect":"read","layer":"cantina","reason":"no translation is applied on this node; every label is the source's own text"},{"verb":"save","lit":false,"effect":"watch-declaration","layer":"workshop","reason":"saving applies to a configured Watch; configure one around this node first (free), then save it"},{"verb":"deliver","lit":false,"effect":"watch-declaration","layer":"workshop","reason":"delivery applies to a saved Watch"},{"verb":"format","lit":false,"effect":"watch-declaration","layer":"workshop","reason":"output format applies to a saved Watch"},{"verb":"deltaR","lit":false,"effect":"read","layer":"workshop","reason":"Delta R needs a saved Watch with a previous reading"},{"verb":"read","lit":false,"effect":"read","layer":"docking-bay","reason":"one-time Reads are parked until the Commander decides their shape (#938)"}]}