{"schema":"sb.node.v1","id":"sb:e/abd5d81d9a17659ea43383f3","kind":"entity","label":{"text":"tp53","locale":"en"},"identity":{"anchor":"label:en:tp53","strength":"label"},"asOf":{"knowledgeCutoff":"2026-10-10T23:27:45.667496+00:00","snapshot":"deploy 732c593e481f0612eaf0387c3ba30665687d84e3"},"lens":{"kind":"public"},"build":{"plane":"projected","builtFrom":["entity_graph.slim.json","entity_receipts (deploy asset)","event_graph.json","truth_records (deploy asset)","corroborated_record.json"],"rule":"node-projection.entity@v1"},"standing":{"evidence":{"supporting":59,"separatePublishers":17,"basis":"documents that mention the subject and the outlets that carried them; a mention is evidence the referent is in use, not evidence about any claim","receiptsOnTopic":{"state":"partial","share":0.119,"named":7,"of":59,"basis":"documents whose own title or summary lead names the subject, over every counted document that mentions it anywhere (the entity graph's measurement); receipts are drawn from the former only","blind":["only 12% of the 59 documents measured name the subject in their own text; the rest mention it in passing, so standing.evidence.supporting overstates coverage about it"]}},"admission":{"state":"canonical","reason":"entity graph provenance 'curated'; the node carries no promotion receipt in v1","policy":"EQ-PROMOTION (receipt not carried)"},"disposition":{"state":"served","reason":"public record"},"validity":{"from":"2026-03-31","to":"2026-10-07","basis":"first and last day we saw it mentioned; not the subject's own lifetime"},"measurement":{"state":"partial","blind":["assertion coverage 0.119: about 88% of mentions carry no typed assertion"]}},"dimensions":{"domains":["oncology","pubmed_targeted","precision_medicine"],"activeDays":31,"assertions":{}},"up":[],"upNote":"An entity is a root: it is contained by nothing. Pan out by following R.","children":{"count":5,"byKind":{"observation":5},"items":[{"id":"sb:o/7a7fae1aeaf987541b8d6135","kind":"observation","label":"crc-kras · 2026-09-09 · CAMOR and specific oncogene-driven lncRNAs mediate carcinogenic functions downstream of MYC, mutant KRAS, and mutant TP53","url":"https://www.biorxiv.org/content/10.64898/2026.09.04.749381v1?rss=1"},{"id":"sb:o/8c0d4d50738e609de51e3512","kind":"observation","label":"Front Med (Lausanne) · 2026-08-25 · Fulminant development of a giant pelvic metastasis from microsatellite-stable early-onset sigmoid colon cancer with KRAS and TP53 co-mutations: a case report.","url":"https://doi.org/10.3389/fmed.2026.1900343"},{"id":"sb:o/63fa3a7b00acb76313460350","kind":"observation","label":"Inside Precision Medicine · 2026-09-19 · Tumors Can Hide p53 Neoantigens from T Cells, Study Finds","url":"https://www.insideprecisionmedicine.com/topics/oncology/tumors-can-hide-p53-neoantigens-from-t-cells-study-finds/"},{"id":"sb:o/8aeef21c57112aed73c96411","kind":"observation","label":"Int J Mol Sci · 2026-09-09 · Artificial Intelligence-Based Prediction of Molecular Alterations in Colorectal Cancer Using Routine H&E Whole-Slide Images.","url":"https://doi.org/10.3390/ijms27188025"},{"id":"sb:o/cece586be186f41ad7845b0e","kind":"observation","label":"Mol Ther Oncol · 2026-08-26 · A p53R273H-selective bispecific T cell engager: Computational design and functional validation.","url":"https://doi.org/10.1016/j.omton.2026.201333"}],"cursor":null,"order":"newest first; we keep the 5 newest receipts for this entity whose own title or summary lead (the entity graph's test) names it. Its other observations are counted in standing.evidence.supporting but are not addressable in v1"},"relations":{"count":10,"byKind":{"co-mentioned":10},"items":[{"kind":"relation","label":"co-mentioned with immunotherapy (30 documents)","role":"co-mentioned","relationKind":"co-mentioned","members":2,"id":"sb:r/bc7045c84b7858b8c1addf2e"},{"kind":"relation","label":"co-mentioned with kras (19 documents)","role":"co-mentioned","relationKind":"co-mentioned","members":2,"id":"sb:r/bc1cf9b596486604d25c5de4"},{"kind":"relation","label":"co-mentioned with clinical trials (19 documents)","role":"co-mentioned","relationKind":"co-mentioned","members":2,"id":"sb:r/6a26838418ec5a458b8146fb"},{"kind":"relation","label":"co-mentioned with china (17 documents)","role":"co-mentioned","relationKind":"co-mentioned","members":2,"id":"sb:r/278bf5227091dde71ad95d13"},{"kind":"relation","label":"co-mentioned with united states (17 documents)","role":"co-mentioned","relationKind":"co-mentioned","members":2,"id":"sb:r/64441131a74471f36250dac0"},{"kind":"relation","label":"co-mentioned with colorectal cancer (15 documents)","role":"co-mentioned","relationKind":"co-mentioned","members":2,"id":"sb:r/484347dcc60c695eaab6fdc8"},{"kind":"relation","label":"co-mentioned with ctdna (15 documents)","role":"co-mentioned","relationKind":"co-mentioned","members":2,"id":"sb:r/40e26ca13f2be53d196e4cfc"},{"kind":"relation","label":"co-mentioned with lung cancer (14 documents)","role":"co-mentioned","relationKind":"co-mentioned","members":2,"id":"sb:r/1d6e18b1b7ae4c832613beb5"},{"kind":"relation","label":"co-mentioned with breast cancer (14 documents)","role":"co-mentioned","relationKind":"co-mentioned","members":2,"id":"sb:r/34de07943ff4848597aba553"},{"kind":"relation","label":"co-mentioned with pi3k (13 documents)","role":"co-mentioned","relationKind":"co-mentioned","members":2,"id":"sb:r/d6119443aef5b561a7a72318"}],"cursor":null,"order":"situations first, then claims (the subject's own maintained record, then site-wide corroborated clusters; each label ends with its standing), then co-mentions by shared documents, descending. Co-mentions are the ten strongest the entity graph keeps per entity"},"edge":{"state":"continues"},"links":{"rest":"/api/v1/node/e/abd5d81d9a17659ea43383f3","mcp":"traverse {\"id\":\"sb:e/abd5d81d9a17659ea43383f3\"}","page":"/entity/tp53/"},"limits":{"levelsPerCall":1,"pageSize":10,"maxPageSize":50,"membersMax":50,"statement":"One level per call: depth is 1 and only 1, and there is no whole-graph dump. pageSize 1-50 (default 10); a page limit is a cursor, never an edge. Members are listed up to 50. At most 60 traverse calls a minute per caller (runaway-loop protection, not a meter). One knowledge cutoff is served: the deploy's."},"actions":[{"verb":"unfold","lit":true,"effect":"read","layer":"cantina","call":"traverse {\"id\":\"sb:e/abd5d81d9a17659ea43383f3\",\"level\":\"children\"}"},{"verb":"fold","lit":true,"effect":"read","layer":"cantina","call":"traverse {\"id\":\"sb:e/abd5d81d9a17659ea43383f3\"}"},{"verb":"panOut","lit":false,"effect":"read","layer":"cantina","reason":"An entity is a root: it is contained by nothing. Pan out by following R."},{"verb":"follow","lit":true,"effect":"read","layer":"cantina","call":"traverse {\"id\":\"sb:e/abd5d81d9a17659ea43383f3\",\"level\":\"relations\"}"},{"verb":"receipts","lit":false,"effect":"read","layer":"cantina","reason":"receipts are the observations below this node; unfold to reach them"},{"verb":"edge","lit":true,"effect":"read","layer":"cantina","call":"traverse {\"id\":\"sb:e/abd5d81d9a17659ea43383f3\"}"},{"verb":"asOf","lit":false,"effect":"read","layer":"cantina","reason":"v1 serves one knowledge cutoff, this deploy's; walking an earlier cutoff needs retained history (EQ-REPLAY), which v1 does not keep"},{"verb":"switchObserver","lit":false,"effect":"read","layer":"cantina","reason":"the public record is the same for every observer; traversal through a Watch's lens is not served in v1"},{"verb":"readOriginal","lit":false,"effect":"read","layer":"cantina","reason":"no translation is applied on this node; every label is the source's own text"},{"verb":"save","lit":false,"effect":"watch-declaration","layer":"workshop","reason":"saving applies to a configured Watch; configure one around this node first (free), then save it"},{"verb":"deliver","lit":false,"effect":"watch-declaration","layer":"workshop","reason":"delivery applies to a saved Watch"},{"verb":"format","lit":false,"effect":"watch-declaration","layer":"workshop","reason":"output format applies to a saved Watch"},{"verb":"deltaR","lit":false,"effect":"read","layer":"workshop","reason":"Delta R needs a saved Watch with a previous reading"},{"verb":"read","lit":false,"effect":"read","layer":"docking-bay","reason":"one-time Reads are parked until the Commander decides their shape (#938)"}]}