{"schema":"sb.node.v1","id":"sb:e/feacdd1ea8f1fb676966d5e2","kind":"entity","label":{"text":"kras-mutant","locale":"en"},"identity":{"anchor":"label:en:kras-mutant","strength":"label"},"asOf":{"knowledgeCutoff":"2026-10-10T19:00:35.865848+00:00","snapshot":"deploy b663cc8b34a8931137d702b8e11a6acd5fab341d"},"lens":{"kind":"public"},"build":{"plane":"projected","builtFrom":["entity_graph.slim.json","entity_receipts (deploy asset)","event_graph.json","truth_records (deploy asset)","corroborated_record.json"],"rule":"node-projection.entity@v1"},"standing":{"evidence":{"supporting":51,"separatePublishers":34,"basis":"documents that mention the subject and the outlets that carried them; a mention is evidence the referent is in use, not evidence about any claim","receiptsOnTopic":{"state":"measured","share":0.922,"named":47,"of":51,"basis":"documents whose own title or summary lead names the subject, over every counted document that mentions it anywhere (the entity graph's measurement); receipts are drawn from the former only"}},"admission":{"state":"provisional","reason":"entity graph provenance 'observed'; the node carries no promotion receipt in v1","policy":"EQ-PROMOTION (receipt not carried)"},"disposition":{"state":"served","reason":"public record"},"validity":{"from":"2026-03-11","to":"2026-10-06","basis":"first and last day we saw it mentioned; not the subject's own lifetime"},"measurement":{"state":"partial","blind":["assertion coverage 0.157: about 84% of mentions carry no typed assertion"]}},"dimensions":{"domains":["oncology","pubmed_targeted"],"activeDays":39,"assertions":{}},"up":[],"upNote":"An entity is a root: it is contained by nothing. Pan out by following R.","children":{"count":8,"byKind":{"observation":8},"withheld":{"state":"withheld","count":4,"reason":"4 receipts withheld: no source link (the same rule the topic record applies)"},"items":[{"id":"sb:o/374b14126e62878f7ca784d1","kind":"observation","label":"bioRxiv Cancer Biology · 2026-10-02 · Acute Metabolic Switch by High-Dose Dehydroascorbic Acid: Rapid TCA Cycle Depletion and Early Signature of Methionine Trap within 1 Hour in KRAS-Mutant Cells","url":"https://www.biorxiv.org/content/10.64898/2026.10.01.755313v1?rss=1"},{"id":"sb:o/1aa361f786b2059a11ec0098","kind":"observation","label":"Eur J Med Chem · 2026-09-24 · Design, synthesis, and structural optimization of novel pan-KRAS degrader for the treatment of KRAS-mutant pancreatic cancer.","url":"https://doi.org/10.1016/j.ejmech.2026.119362"},{"id":"sb:o/bc38de013cca9c0bd7137b67","kind":"observation","label":"J Natl Compr Canc Netw · 2026-09-18 · Targeting KRAS-Mutant Lung Cancers.","url":"https://doi.org/10.6004/jnccn.2026.7038"},{"id":"sb:o/03d4783f1eb1d0dada3bbd78","kind":"observation","label":"Cancer Chemother Pharmacol · 2026-09-17 · Main pulmonary artery enlargement during bevacizumab therapy in KRAS-mutant metastatic colon cancer.","url":"https://doi.org/10.1007/s00280-026-04953-2"},{"id":"sb:o/55f03193c4ee8605f8fababe","kind":"observation","label":"Med Oncol · 2026-09-10 · Beyond KRASG12C: emerging therapeutic strategies, patent landscape, and clinical progress in targeting KRAS-mutant cancers.","url":"https://doi.org/10.1007/s12032-026-03392-6"},{"id":"sb:o/43eef626a193acd500f3533d","kind":"observation","label":"crc-digest · 2026-08-29 · Olive Oil Compound Oleocanthal Shows Promise Against KRAS-Mutant CRC","url":"https://doi.org/10.3390/nu18162623"},{"id":"sb:o/5fb6d60510336438c40f9eb4","kind":"observation","label":"J Drug Target · 2026-09-28 · Molecular Mechanisms of Resistance to KRASG12C Inhibitors in NSCLC- From Genomic Evolution to TME Adaptation.","url":"https://doi.org/10.1080/1061186X.2026.2741202"},{"id":"sb:o/7e1b57a466ba6a1c08999f92","kind":"observation","label":"Cell Rep · 2026-09-17 · PADI-dependent mitochondrial adaptation drives resistance to KRAS inhibitors.","url":"https://doi.org/10.1016/j.celrep.2026.118016"}],"cursor":null,"order":"newest first; we keep the 8 newest receipts for this entity whose own title or summary lead (the entity graph's test) names it. Its other observations are counted in standing.evidence.supporting but are not addressable in v1"},"relations":{"count":3,"byKind":{"co-mentioned":3},"items":[{"kind":"relation","label":"co-mentioned with kras (51 documents)","role":"co-mentioned","relationKind":"co-mentioned","members":2,"id":"sb:r/01eda8a71d27fc6bc646c93f"},{"kind":"relation","label":"co-mentioned with colorectal cancer (20 documents)","role":"co-mentioned","relationKind":"co-mentioned","members":2,"id":"sb:r/e83f11e9d2a47b87e157ca15"},{"kind":"relation","label":"co-mentioned with lung cancer (9 documents)","role":"co-mentioned","relationKind":"co-mentioned","members":2,"id":"sb:r/62456a9617f494787f94e37d"}],"cursor":null,"order":"situations first, then claims (the subject's own maintained record, then site-wide corroborated clusters; each label ends with its standing), then co-mentions by shared documents, descending. Co-mentions are the ten strongest the entity graph keeps per entity"},"edge":{"state":"continues"},"links":{"rest":"/api/v1/node/e/feacdd1ea8f1fb676966d5e2","mcp":"traverse {\"id\":\"sb:e/feacdd1ea8f1fb676966d5e2\"}","page":"/entity/kras-mutant/"},"limits":{"levelsPerCall":1,"pageSize":10,"maxPageSize":50,"membersMax":50,"statement":"One level per call: depth is 1 and only 1, and there is no whole-graph dump. pageSize 1-50 (default 10); a page limit is a cursor, never an edge. Members are listed up to 50. At most 60 traverse calls a minute per caller (runaway-loop protection, not a meter). One knowledge cutoff is served: the deploy's."},"actions":[{"verb":"unfold","lit":true,"effect":"read","layer":"cantina","call":"traverse {\"id\":\"sb:e/feacdd1ea8f1fb676966d5e2\",\"level\":\"children\"}"},{"verb":"fold","lit":true,"effect":"read","layer":"cantina","call":"traverse {\"id\":\"sb:e/feacdd1ea8f1fb676966d5e2\"}"},{"verb":"panOut","lit":false,"effect":"read","layer":"cantina","reason":"An entity is a root: it is contained by nothing. Pan out by following R."},{"verb":"follow","lit":true,"effect":"read","layer":"cantina","call":"traverse {\"id\":\"sb:e/feacdd1ea8f1fb676966d5e2\",\"level\":\"relations\"}"},{"verb":"receipts","lit":false,"effect":"read","layer":"cantina","reason":"receipts are the observations below this node; unfold to reach them"},{"verb":"edge","lit":true,"effect":"read","layer":"cantina","call":"traverse {\"id\":\"sb:e/feacdd1ea8f1fb676966d5e2\"}"},{"verb":"asOf","lit":false,"effect":"read","layer":"cantina","reason":"v1 serves one knowledge cutoff, this deploy's; walking an earlier cutoff needs retained history (EQ-REPLAY), which v1 does not keep"},{"verb":"switchObserver","lit":false,"effect":"read","layer":"cantina","reason":"the public record is the same for every observer; traversal through a Watch's lens is not served in v1"},{"verb":"readOriginal","lit":false,"effect":"read","layer":"cantina","reason":"no translation is applied on this node; every label is the source's own text"},{"verb":"save","lit":false,"effect":"watch-declaration","layer":"workshop","reason":"saving applies to a configured Watch; configure one around this node first (free), then save it"},{"verb":"deliver","lit":false,"effect":"watch-declaration","layer":"workshop","reason":"delivery applies to a saved Watch"},{"verb":"format","lit":false,"effect":"watch-declaration","layer":"workshop","reason":"output format applies to a saved Watch"},{"verb":"deltaR","lit":false,"effect":"read","layer":"workshop","reason":"Delta R needs a saved Watch with a previous reading"},{"verb":"read","lit":false,"effect":"read","layer":"docking-bay","reason":"one-time Reads are parked until the Commander decides their shape (#938)"}]}